LOSS-OF-FUNCTION MUTATIONS IN RAB ESCORT PROTEIN 1 (REP-1) AFFECT INTRACELLULAR TRANSPORT IN FIBROBLASTS AND MONOCYTES OF CHOROIDEREMIA PATIENTS.

Loss-of-function mutations in Rab escort protein 1 (REP-1) affect intracellular transport in fibroblasts and monocytes of choroideremia patients.

BACKGROUND: Choroideremia (CHM) is a progressive X-linked retinopathy caused by mutations in the CHM gene, which encodes Rab escort protein-1 (REP-1), an escort protein involved in the prenylation of Rabs.Under-prenylation of certain Rabs, as a result of loss of function mutations in REP-1, could affect vesicular trafficking, exocytosis and secreti

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Payment for ecosystem services (PES): a holistic tool for sustainable forest management-a case study from Pakistan

Abstract Economic valuation of ecosystem services is a new concept in forest management.Economic valuation provides basis for payment for RAPID MASS CHOCO ORANGE PUDDING ecosystem services (PES).Therefore, objective of this study was to evaluate eco-tourism and carbon stock services of the Maindam valley, District Swat, Pakistan.For the carbon stoc

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